POS1328 HAVE THE CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AN EXCESS OF ADIPOSITY?

Background: In recent years, several studies show contradictory results regarding body composition in juvenile idiopathic arthritis. Adiposity Rheumatoid Arthritis and Psoriasic has been associated to inflammatory activity, but it is not clear what happens JIA. Objectives: To describe the anthropometric parameters of patients with JIA compared healthy controls analyze risk factors patients. Methods: Observational cross-sectional study spanish children aged 4-15 years matched for age sex. We recorded epidemiological variablesanthropometric parameters, clinical data validated physical activity questionnaires. Body was measured using dual-energy x-ray absorptiometry (DXA), included total mass (kg), fat (g), lean android gynoid mass. The index (FMI) defined as (kg)/height squared (m 2 ) fat-free (FFMI) ). Descriptive, bivariete two multivariate models were constructed identify obesity Results: 160 subjects: 80 controls.The baseline characteristics both groups are shown Table 1. No differences found between BMI (p=0.936), (p = 0.449), 0.793) legs, arms trunk, or questionnaire 0.582). were: time biological drug (OR [95% CI] 1.12 [1.01-1.04]; p 0.042) sedentary lifestyle 3.50 [1.18-7.35]; 0.023); while (ß 0.30 [0.16-1.41]; p= 0.014), (JDAS) 0.44 [0.16-1.08]; 0.009) -0.22 [-0.10,-0.28]; 0.031). Baseline Variable (n=80) Controls P-value Sex, girls n (% 56 (70.0) 57 (71.3) 0.862 Age, mean (SD 10.7 (3.2) 10.2 0.893 Disease duration (years) JIA, 6.5 (3.7) subtype Systemic, 9 (11.3) Oligoarticular persistent, 38 (47.5) extended, 13 (16.3) Factor-positive polyarticular, 1 (1.3) Factor-negative 19(23.8) CRP (mg/l), 4,8 (9,5) ESR (mm/h), 8.8 (7,3) JADAS27, (4.0) CHAQ, 0.17 (0.4) Treatment DMARDs (synthetic), 42 (52.5) (biological), 24 (30.0) Anti IL-1, 4 (16.7) IL-6, (8.3) TNF-α, 18 (75.0) synthetic, (months), (±SD 51 (37.5) biological, 19.7 (28.4) 55.8 (38.0) Cumulative corticoisteroids dose, median (range 11.3 (0.12-870) Abreviaturas; JIA: idhipathic arthritis; SD: standart deviation; CRP: C-reactive protein; VSG:erytrocyte sedimentation rate; JADAS27: Juvenile Activity Score; CHAQ: Childhood Health Assessment; DMARD: disease-modifyng anti-rheumatic drug. Conclusion: Children have adiposity similar controls. Inflammatory by JDAS measurements such (BMI). References: [1]Grönlund et al arthritis low increased adiposity. Scand J Rheumatol 2014. [2]Giani al. Influence Overweight Obesity on Response Idiopathic Arthritis. Front Pharmacol 2019 [3]Wiech phase angle an indicator nutritional status Pediatric Rheumatology 2018 [4]Alvarez-Nemegyei Association Overweight/Obesity Clinical rheumatoid Reumatol Clin 2020 Disclosure Interests: None declared